KORELASI ANTARA JUMLAH LEUKOSIT DAN KADAR HEMOGLOBIN PADA PASIEN DEMAM TIFOID
Keywords:
demam tifoid, leukosit, hemoglobin, typhoid fever, leukocytesAbstract
ABSTRAK
Demam tifoid termasuk infeksi akibat bakteri Salmonella typhi yang menjadi salah satu permasalahan kesehatan di Indonesia. Infeksi tersebut dapat memengaruhi berbagai parameter hematologi, termasuk jumlah leukosit dan kadar hemoglobin. Namun, penelitian mengenai hubungan antara kedua parameter tersebut pada pasien demam tifoid masih terbatas, khususnya di RSAU dr. Efram Harsana Lanud Iswahjudi Magetan. Studi ini bertujuan untuk mengetahui korelasi antara jumlah leukosit dan kadar hemoglobin pada pasien demam tifoid. Studi ini menerapkan metode analitik observasional dengan pendekatan cross-sectional. Sebanyak 32 pasien demam tifoid digunakan sebagai sampel dengan kriteria inklusi yang telah ditetapkan dan teknik purposive sampling. Sampel yang diperiksa berupa darah vena yang dianalisis menggunakan Hematology Analyzer-170 di Laboratorium RSAU dr. Efram Harsana Lanud Iswahjudi Magetan. Pemeriksaan mencakup jumlah leukosit dan kadar hemoglobin. Distribusi data dianalisis menggunakan uji normalitas Shapiro-Wilk, sedangkan hubungan kedua variabel diuji dengan korelasi Spearman. Rerata jumlah leukosit adalah 9,3262 (SD 4,96475), sedangkan rerata kadar hemoglobin adalah 12,9813 g/dL (SD 1,67764). Mayoritas responden memiliki jumlah leukosit normal sebanyak 59,4% dan kadar hemoglobin normal sebanyak 84,4%. Analisis dengan korelasi Spearman memperoleh koefisien sebesar 0,136 dan nilai signifikansi (p-value) 0,458 (>0,05). Hasil analisis menunjukkan bahwa hubungan antara jumlah leukosit dan kadar hemoglobin pada pasien demam tifoid tidak bermakna secara statistik. Koefisien korelasi menunjukkan arah hubungan positif dengan kekuatan yang sangat lemah. Berdasarkan hasil penelitian, pada pasien demam tifoid di RSAU dr. Efram Harsana Lanud Iswahjudi Magetan tidak ditemukan korelasi antara jumlah leukosit dan kadar hemoglobin.
ABSTRACT
Typhoid fever is an infection caused by the bacterium Salmonella typhi and represents a significant health issue in Indonesia. This infection can affect various hematological parameters, including leukocyte counts and hemoglobin levels. However, research regarding the relationship between these two parameters in typhoid fever patients remains limited, particularly at RSAU dr. Efram Harsana, Iswahjudi Air Force Base, Magetan. This study aimed to determine the correlation between leukocyte counts and hemoglobin levels in typhoid fever patients. An observational analytic method with a cross-sectional approach was employed. A sample of 32 typhoid fever patients was selected using purposive sampling based on established inclusion criteria. Venous blood samples were analyzed using a Hematology Analyzer-170 at the laboratory of RSAU dr. Efram Harsana, Iswahjudi Air Force Base, Magetan. The analysis covered leukocyte counts and hemoglobin levels. Data distribution was assessed using the Shapiro-Wilk normality test, while the relationship between the two variables was tested using Spearman's correlation. The mean leukocyte count was 9.3262 (SD 4.96475), and the mean hemoglobin level was 12.9813 g/dL (SD 1.67764). The majority of respondents exhibited normal leukocyte counts (59.4%) and normal hemoglobin levels (84.4%). Spearman's correlation analysis yielded a coefficient of 0.136 and a significance value (p-value) of 0.458 (>0.05). The results indicate that the relationship between leukocyte counts and hemoglobin levels in typhoid fever patients was not statistically significant. The correlation coefficient showed a positive relationship with very weak strength. Based on the study findings, no correlation was found between leukocyte counts and hemoglobin levels in typhoid fever patients at RSAU dr. Efram Harsana, Iswahjudi Air Force Base, Magetan.
Downloads
References
Ayaz, M., Khan, I. U., Khan, N., & Nabi, M. (2025). Clinical and hematological profile of patients presenting with extensively drug-resistant enteric fever. Indus Journal of Bioscience Research, 3(5), 900–905. https://doi.org/10.70749/ijbr.v3i5.1652
Chaudhary, V., R., B. R., & Ramesh Kumar, K. (2025). Haematological profile in typhoid fever: An update from a tertiary rural hospital. International Journal of Community Medicine and Public Health, 12(11), 5177–5180. https://doi.org/10.18203/2394-6040.ijcmph20253702
Deng, Q., Yang, S., Sun, L., Dong, K., Li, Y., Wu, S., & Huang, R. (2021). Salmonella effector SpvB aggravates dysregulation of systemic iron metabolism via modulating the hepcidin–ferroportin axis. Gut Microbes, 13(1), Article 1849996. https://doi.org/10.1080/19490976.2020.1849996
Devita, N., Riski, M. S., & Marufi, R. (2024). Changes in hematological parameters of typhoid fever patients at PKU Bantul Hospital, Yogyakarta. Jambi Medical Journal, 12(2), 163–171. https://doi.org/10.22437/jmj.v12i2.31587
Dinas Kesehatan Provinsi Jawa Timur. (2024). Profil kesehatan Provinsi Jawa Timur 2024.
Dwi, Y., Gaol, R. L., Perangin-angin, I. H., & Tundang, G. (2024). Gambaran pengetahuan pada ibu tentang demam tifoid anak di Ruang Theresia Rumah Sakit Santa Elisabeth Medan tahun 2024. Nursing Applied Journal, 2(4), 130–138. https://doi.org/10.57213/naj.v2i4.416
Garrett, D. O., Longley, A. T., Aiemjoy, K., Yousafzai, M. T., Hemlock, C., Yu, A. T., Vaidya, K., Tamrakar, D., Saha, S., Bogoch, I. I., Date, K., Saha, S., Islam, M. S., Sayeed, K. M. I., Bern, C., Shakoor, S., Dehraj, I. F., Mehmood, J., Sajib, M. S. I., … Luby, S. P. (2022). Incidence of typhoid and paratyphoid fever in Bangladesh, Nepal, and Pakistan: Results of the Surveillance for Enteric Fever in Asia Project. The Lancet Global Health, 10(7), e978–e988. https://doi.org/10.1016/S2214-109X(22)00119-X
Hartanto, D. (2021). Diagnosis dan tatalaksana demam tifoid pada dewasa. Cermin Dunia Kedokteran, 48(1), 5–9. https://doi.org/10.55175/cdk.v48i1.1255
Hijriyani, L., Fihiruddin, F., Pauzi, I., & Resnhaleksmana, E. (2026). Differences in hemoglobin levels in infected patients Salmonella typhi with Salmonella paratyphi based on antibody titer. Jurnal Analis Medika Biosains (JAMBS), 13(1). https://jambs.poltekkes-mataram.ac.id/index.php/home/article/view/445
Lin, S., Lv, C., Geng, M., Gao, R., Sun, Y., Wang, Y., Zheng, Y., Tang, T., Shan, C., Tian, Y., Qiu, Y., Ma, J., Zhang, Y., Yang, Y., Xu, Q., Wang, G., Zhang, Y., Li, Q., Wang, L., … Liu, W. (2025). Epidemiological analysis of infectious diseases in older people in China from 2014 to 2022: A population-based study. The Lancet Regional Health – Western Pacific, 64, Article 101729. https://doi.org/10.1016/j.lanwpc.2025.101729
Liu, G., Zhang, X., Cao, Q., Chen, T., Hu, B., & Shi, H. (2025). The global burden of typhoid and paratyphoid fever from 1990 to 2021 and the impact on prevention and control. BMC Infectious Diseases, 25(1), 1–16. https://doi.org/10.1186/s12879-025-11223-8
Lukman, N. A., Syamsuddin, F. A., & Hariadi, A. (2024). Profil hematologi penderita demam tifoid yang dirawat inap di RSUD Labuang Baji Makassar tahun 2021–2022. Bosowa Medical Journal, 2(2), 92–96. https://doi.org/10.56326/bmj.v2i2.2459
Majidah, L., Ekowati, L., & Wijaya, D. W. (2023). Pemeriksaan kadar hemoglobin (Hb) dan laju endap darah (LED) pada penderita demam tifoid. Jurnal Insan Cendekia, 10(3), 227–235.
Mu'arofah, B., Wardani, S. K., & Rukmana, S. (2023). Hubungan adanya bakteri Salmonella typhi dengan kadar hemoglobin pada penderita demam tifoid yang berdampak anemia di RS Kota Kediri. Judika (Jurnal Nusantara Medika), 7(1), 8–22. https://doi.org/10.29407/judika.v7i1.20098
Nemeth, E., & Ganz, T. (2021). Hepcidin-ferroportin interaction controls systemic iron homeostasis. International Journal of Molecular Sciences, 22(12), Article 6493. https://doi.org/10.3390/ijms22126493
Nusrat, N., Islam, R., Paul, N., Rahman, N., & Krishnapillai, A. (2022). Clinical and laboratory features of enteric fever in children and antibiotic sensitivity pattern in a tertiary care hospital of a low- and middle-income country. Cureus, 14(10), Article e30784. https://doi.org/10.7759/cureus.30784
Piovani, D., Figlioli, G., Nikolopoulos, G. K., & Bonovas, S. (2024). The global burden of enteric fever, 2017–2021: A systematic analysis from the Global Burden of Disease Study 2021. EClinicalMedicine, 77, Article 102883. https://doi.org/10.1016/j.eclinm.2024.102883
Prapaiwong, P., Ruksakulpiwat, S., Jariyasakulwong, P., Kasetkala, P., Puwarawuttipanit, W., & Pongsuwun, K. (2025). Determinants of anemia among patients with chronic kidney disease: A systematic review of empirical evidence. Journal of Multidisciplinary Healthcare, 18, 3765–3780. https://doi.org/10.2147/JMDH.S535423
Sihombing, J. R., Rugun, H., Nainggolan, N., Elizabeth, N., Sipahutar, R., & Siagian, S. E. (2024). Karakteristik hitung jumlah sel leukosit pasien demam tifoid yang dirawat di RSU Martha Friska Multatuli Medan. Malahayati Nursing Journal, 6(6), 2374–2382. https://doi.org/10.33024/mnj.v6i6.14953
Thu, H. T. (2022). Relationship between fever level and leukocyte levels in children with typhoid fever. Journal of Asian Multicultural Research for Medical and Health Science Study, 3(4), 16–21. https://doi.org/10.47616/jamrmhss.v3i4.349
Tobing, J. F. J. (2024). Demam tifoid. Ikraith-Humaniora, 8(2), 463–470. https://journals.upi-yai.ac.id/index.php/ikraith-humaniora/article/view/3974
Widat, Z., Jumadewi, A., & Hadijah, S. (2022). Gambaran jumlah leukosit pada penderita demam tifoid. HEALTHY: Jurnal Inovasi Riset Ilmu Kesehatan, 1(3), 142–147. https://doi.org/10.51878/healthy.v1i3.1461
Wiratma, D. Y., Purba, D., & Aritonang, E. (2022). Pemeriksaan hemoglobin pada penderita demam tifoid di RS Islam Malahayati Medan tahun 2022. Jurnal Teknologi Kesehatan dan Ilmu Sosial (TEKESNOS), 4(1), 187–191. https://e-journal.sari-mutiara.ac.id/index.php/tekesnos/article/view/3105
Zuleika, P., & Legiran. (2022). Cross-sectional study as research design in medicine. Archives of the Medicine and Case Reports, 3(2), 256–259. https://doi.org/10.37275/AMCR.v3i2.193
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2027 Nadia Aulia Putri, Dwi Krihariyani, Wisnu Istanto
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
CC Attribution-NonCommercial-ShareAlike 4.0
