ANALISIS WAKTU AKUISISI TERHADAP CITRA PADA PEMERIKSAAN SIDIK SELURUH TUBUH POST-TERAPI I-131 KEDOKTERAN NUKLIR DENGAN KLINIS KANKER TIROID DI RSUP DR. HASAN SADIKIN BANDUNG
DOI:
https://doi.org/10.51878/healthy.v6i1.15694Keywords:
I-131, kualitas citra, laju paparan, scan speed, SST Post-TerapiAbstract
Post-therapy whole body scan (WBS) I-131 acquisition parameters such as scan speed are adjusted according to the patient's radiation exposure rate to optimize clinical workflow efficiency. This study aims to determine the correlation between exposure rate, scan speed, and planar whole body image quality during post-therapy WBS I-131 at the Nuclear Medicine Installation of RSUP Dr. Hasan Sadikin Bandung. This quantitative analytical retrospective study with an observational approach utilized secondary protocol data from 30 thyroid cancer patients acquired between January and February 2026. Image quality was visually evaluated by a nuclear medicine specialist using a 1–5 visual grading scale, and the data were analyzed using the Spearman rank correlation test (p < 0.05). The results demonstrated a significant negative correlation between scan speed and image quality (r = -0.389; p = 0.034), alongside a significant positive correlation between exposure rate and scan speed (r = 0.438; p = 0.015). Conversely, no statistically significant correlation was identified between patient exposure rate and final image quality (r = -0.010; p = 0.959).
References
Arisa Putri, A. A., Indra, B., & Qodir, N. (2025). Characteristics of thyroid carcinoma patients in the inpatient department of Dr. Mohammad Hoesin General Hospital from January 2020 to December 2022. Indonesian Journal of Cancer, 19(2), 211–216. https://doi.org/10.33371/ijoc.v19i2.1281
Avram, A. M., Giovanella, L., Greenspan, B., Lawson, S. A., Luster, M., Van Nostrand, D., Peacock, J. G., Petranovi? Ov?ari?ek, P., Silberstein, E., Tulchinsky, M., Verburg, F. A., & Vrachimis, A. (2022). SNMMI procedure standard/EANM practice guideline for nuclear medicine evaluation and therapy of differentiated thyroid cancer: Abbreviated version. Journal of Nuclear Medicine, 63(6), 15N–35N. https://doi.org/10.2967/jnumed.122.264104
Bailey, D. L., Humm, J. L., Todd-Pokropek, A., & van Aswegen, A. (2014). Nuclear medicine physics: A handbook for teachers and students. International Atomic Energy Agency.
Bhatia, N., Dhingra, V. K., Mittal, P., & Saini, S. (2023). Radiation safety and external radiation exposure rate of patients receiving I-131 therapy for hyperthyroidism and remnant ablation as outpatient: An institutional experience. World Journal of Nuclear Medicine, 22(3), 203–207. https://doi.org/10.1055/s-0043-1771285
Cherry, S. R., Sorenson, J. A., & Phelps, M. E. (2012). Physics in nuclear medicine (4th ed.). Elsevier Saunders.
de Vries–Huizing, D. M. V., Sinaasappel, M., Dekker, M. C., Stokkel, M. P. M., & der Veen, B. J. de W. (2020). 177Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction. Journal of Applied Clinical Medical Physics, 21(9), 272–277. https://doi.org/10.1002/acm2.12991
Eka Sriyani, M., Ayu Utami, D., Dwike Susilo, M., Maria Widyasari, E., Marzuki, M., Juwita Sugiharti, R., & Nuraeni, W. (2019). Synthesis of 131I labeled quercetin through oxidation method using chloramine-T for cancer radiopharmaceuticals. Indonesian Journal of Chemistry, 19(4), 841–848. https://doi.org/10.22146/ijc.34512
Forma, A., K?odnicka, K., Paj?k, W., Flieger, J., Teresi?ska, B., Januszewski, J., & Baj, J. (2025). Thyroid cancer: Epidemiology, classification, risk factors, diagnostic and prognostic markers, and current treatment strategies. International Journal of Molecular Sciences, 26(11), Article 5173. https://doi.org/10.3390/ijms26115173
Güveni?, A., & Aytaç, B. (2023). Improving the quantification accuracy of Tc-99m MIBI dual-phase parathyroid SPECT/CT: A Monte Carlo simulation study. Natural and Applied Sciences Journal, 6(2), 9–23. https://doi.org/10.38061/idunas.1325839
Kumar, P., Bal, C., & Damle, N. A. (2024). Optimal time of diagnostic and posttherapeutic Iodine-131 whole-body scan in post-operative pediatric and young adult differentiated thyroid cancer patients. Indian Journal of Nuclear Medicine, 39(6), 428–435. https://doi.org/10.4103/ijnm.ijnm_133_24
Liu, S., Zuo, R., Yang, T., Pang, H., & Wang, Z. (2022). A semiquantitative study of the optimal whole-body imaging time after 131I therapy for differentiated thyroid cancer. Frontiers in Endocrinology, 13, Article 955387. https://doi.org/10.3389/fendo.2022.955387
Mada, M., Attard, M., & Pietrzak, A. (2020). Hybrid imaging in conventional nuclear medicine: EANM technologist's guide. European Association of Nuclear Medicine.
McIntosh, L., Jackson, P., Emmerson, B., Buteau, J. P., Alipour, R., Kong, G., & Hofman, M. S. (2024). Quantitative calibration of Tb-161 SPECT/CT in view of personalised dosimetry assessment studies. EJNMMI Physics, 11(1), Article 18. https://doi.org/10.1186/s40658-024-00611-9
Mihailovi?, J. (2024). Pre-treatment and post-treatment I-131 imaging in differentiated thyroid carcinoma. Journal of Clinical Medicine, 13(7), Article 1984. https://doi.org/10.3390/jcm13071984
Mutohar, A., Setiabudi, W., & Shintawati, R. (2017). Laju paparan dan dosis radiasi dari pasien terapi kelainan kelenjar tiroid dengan pemberian radiofarmaka Iodium-131. Youngster Physics Journal, 6(1), 22–31. https://doi.org/10.14710/ypj.v6i1.16104
Nai, Y., Schaefferkoetter, J., Fakhry-Darian, D., O’Doherty, S., Totman, J. J., Conti, M., Townsend, D. W., Sinha, A., Tan, T.-H., Tham, I. W. K., Alexander, D. C., & Reilhac, A. (2020). Validation of low-dose lung cancer PET-CT protocol and PET image improvement using machine learning. Physica Medica: European Journal of Medical Physics, 81, 285–294. https://doi.org/10.1016/j.ejmp.2020.11.027
Santos, A., Pietrzak, A., & Terwinghe, C. (2022). Radionuclide therapy management: A technologists' guide. European Association of Nuclear Medicine.
Sergieva, S., Sofiyanski, T., Robev, B., Dimcheva, M., & Farikova, A. (2024). Retrospective study of post-treatment 131I SPECT/CT imaging for personalizing therapy of patients with differentiated thyroid cancer. Folia Medica, 66(6), 776–786. https://doi.org/10.3897/folmed.66.e139177
Spanu, A., Nuvoli, S., Marongiu, A., Gelo, I., Mele, L., De Vito, A., Rondini, M., & Madeddu, G. (2021). The diagnostic usefulness of 131I-SPECT/CT at both radioiodine ablation and during long-term follow-up in patients thyroidectomized for differentiated thyroid carcinoma: Analysis of tissue risk factors ascertained at surgery and correlated with metastasis appearance. Diagnostics, 11(8), Article 1504. https://doi.org/10.3390/diagnostics11081504
Stokkel, M., & Van Leeuwenhoekziekenhuis, A. (2016). Iodine total body scintigraphy: Clinical protocol. Netherlands Cancer Institute.
Sun, Z., Huang, F., Zhang, Y., Jin, Y., Yang, S., & Gao, S. (2026). Analysis of external dose rate attenuation and its related factors in differentiated thyroid carcinoma patients following I-131 therapy. EJNMMI Physics, 13(1), Article 845. https://doi.org/10.1186/s40658-026-00845-9
Szumowski, P., Abdelrazek, S., Iwanicka, D., Mojsak, M., Syka?a, M., ?ukowski, ?., Siewko, K., Adamska, A., Maliszewska, K., Pop?awska-Kita, A., Szelachowska, M., Kr?towski, A., & My?liwiec, J. (2021). Dosimetry during adjuvant 131I therapy in patients with differentiated thyroid cancer: Clinical implications. Scientific Reports, 11(1), Article 14210. https://doi.org/10.1038/s41598-021-93431-1
Texte, E., Gouel, P., Thureau, S., Lequesne, J., Barrès, B., Edet?Sanson, A., Decazes, P., Véra, P., & Hapdey, S. (2020). Impact of the Bayesian penalized likelihood algorithm (Q.Clear®) in comparison with the OSEM reconstruction on low contrast PET hypoxic images. EJNMMI Physics, 7(1), Article 28. https://doi.org/10.1186/s40658-020-00300-3
Uppot, R. N. (2018). Technical challenges of imaging & image-guided interventions in obese patients. The British Journal of Radiology, 91(1089), Article 20170931. https://doi.org/10.1259/bjr.20170931
Verrecchia?Ramos, E., Morel, O., Beauchat, V., Denet, S., Sidikou, A. D., Ginet, M., Pfletschinger, E., Teodor, L., Trombowsky, M., Verdier, J., Vère, C., Retif, P., & Mahmoud, S. B. (2023). Personalization of 99mTc-sestamibi activity in SPECT/CT myocardial perfusion imaging with the cardiofocal SmartZoom® collimator. EJNMMI Physics, 10(1), Article 23. https://doi.org/10.1186/s40658-023-00545-8
Yordanova, A., Eppard, E., Kürpig, S., Bundschuh, R. A., Schönberger, S., Gonzalez-Carmona, M., Feldmann, G., Ahmadzadehfar, H., & Essler, M. (2017). Theranostics in nuclear medicine practice. OncoTargets and Therapy, 10, 4821–4828. https://doi.org/10.2147/OTT.S140671
Yu, Z., Rahman, M. A., Laforest, R., Schindler, T. H., Gropler, R. J., Wahl, R. L., Siegel, B. A., & Jha, A. K. (2023). Need for objective task?based evaluation of deep learning?based denoising methods: A study in the context of myocardial perfusion SPECT. Medical Physics, 50(7), 4122–4137. https://doi.org/10.1002/mp.16407
Zhang, R., Wang, M., Zhou, Y., Wang, S., Shen, Y., Li, N., Wang, P., Tan, J., Meng, Z., & Jia, Q. (2021). Impacts of acquisition and reconstruction parameters on the absolute technetium quantification of the cadmium–zinc–telluride-based SPECT/CT system: A phantom study. EJNMMI Physics, 8(1), Article 66. https://doi.org/10.1186/s40658-021-00412-4















