PENGEMBANGAN PERBAN CAIR BERBASIS EKSTRAK RUMPUT BELULANG (ELEUSINE INDICA) SEBAGAI SEDIAAN PERAWATAN LUKA BERBASIS BAHAN ALAM
DOI:
https://doi.org/10.51878/vocational.v7i1.16391Keywords:
Eleusine indica, perban cair, aktivitas antioksidan, formulasi, luka superfisialAbstract
Superficial skin wounds require effective physical protection to minimize environmental contamination while maintaining a balanced microenvironment for tissue repair. A liquid bandage represents a practical modern topical formulation capable of forming a transparent, flexible barrier that conforms to anatomical skin contours. This study aimed to formulate EleuSeal, a novel liquid bandage incorporating goosegrass (Eleusine indica) extract, and evaluate its total phenolic content, antioxidant capacity, and physicochemical properties. The experimental procedures included ethanolic maceration, Folin–Ciocalteu total phenolic assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging evaluation, and physical characterization performed in triplicate (n = 3). The results demonstrated a total phenolic content of 10.20 ± 0.35 mg GAE/g extract and significant antioxidant activity with an 〖"IC" 〗_50 value of 1.57 ± 0.04 mg/mL (R^2=0.998). The optimized EleuSeal formulation exhibited a skin-compatible pH of 5.02 ± 0.08, a rapid drying time of 98.67 ± 4.16 seconds, excellent film flexibility without cracking, low surface tackiness, and balanced water washability. These findings demonstrate that EleuSeal holds promising potential as a functional bio-based liquid dressing for superficial abrasions, although future in vivo safety and wound closure assays remain essential.
ABSTRAK
Luka kulit superfisial membutuhkan perlindungan fisik yang efektif untuk meminimalkan paparan kontaminan lingkungan serta menjaga kelembapan mikro guna mendukung regenerasi sel. Perban cair (liquid bandage) merupakan alternatif sediaan topikal modern yang aplikatif karena mampu membentuk lapisan film transparan dan fleksibel mengikuti kontur kulit. Penelitian ini bertujuan untuk memformulasi sediaan perban cair EleuSeal berbasis ekstrak rumput belulang (Eleusine indica) serta mengevaluasi kandungan fenolik total, aktivitas antioksidan, dan sifat fisiknya. Pengujian dilakukan melalui ekstraksi maserasi dengan pelarut etanol, penetapan kadar fenolik total (Folin–Ciocalteu), pengujian aktivitas antioksidan (DPPH assay), dan evaluasi fisik sediaan yang diulang sebanyak tiga kali (triplo). Hasil penelitian menunjukkan ekstrak rumput belulang mengandung fenolik total sebesar 10,20 ± 0,35 mg GAE/g dan aktivitas penangkapan radikal bebas dengan nilai 〖"IC" 〗_50 sebesar 1,57 ± 0,04 mg/mL (R^2=0,998). Formulasi EleuSeal menghasilkan sediaan dengan pH fisiologis 5,02 ± 0,08, waktu pengeringan cepat selama 98,67 ± 4,16 detik, lapisan film yang fleksibel tanpa retak, daya lekat rendah, serta sifat kemudahan pencucian yang seimbang. Karakteristik ini membuktikan bahwa EleuSeal memiliki potensi aplikatif yang baik sebagai sediaan perban cair pelindung luka ringan, meskipun pengujian biokompatibilitas dan efikasi penyembuhan luka secara in vivo tetap diperlukan pada penelitian lanjutan.
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